The Nurses’s RX no. 19: Wait… what actually are peptides?

Okay, peptide-curious people…

If you’ve been seeing people talk about peptides, peps, peppers, 🌶🌊, Pɛp+ḷꝺΣ or whatever coded little nickname the internet is using this week and you’ve been wondering what everyone is even talking about… this one’s for you.

I wrote a full blog post about it…. here’s the TLDR version👇

Blog graphic asking “What are peptides?” with peptide molecule imagery, a vial, syringe, serum bottle, face cream, and question prompts about peptide uses, amino acids, proteins, FDA approval, peptide sources, and why women over 40 are hearing about peptides.
A nurse led guide to what peptides are, how they work, what peptides are used for, and what to know before starting peptide therapy.

What are peptides????

The easiest way to think about peptides is to think of them as language. Amino acids are the letters. Peptides are short words or phrases made from those letters. Proteins are the longer sentences, paragraphs, or full instruction manuals your body builds from them.

So when people say peptides are “building blocks,” that’s the part they mean. Peptides are short chains of amino acids, and those little chains can act like messengers in the body. Depending on the peptide, that message might be linked to skin, energy, recovery, metabolism, sleep, libido, or cognitive support.

That’s why “I take peptides” doesn’t really tell you much by itself. Peptides are a whole category, not one single thing. Some are talked about for energy and cellular function. Some are being researched for skin health, collagen support, tissue repair, recovery, metabolic support, sleep, libido, or cognitive wellness. The goal depends on the peptide, the person, and the reason someone is using it.

This is also why I’m not a fan of the internet acting like there is one “best peptide” for everyone. The better question is, “What am I actually trying to support, and does this make sense with my health history, medications, goals, and provider review?”

And yes, we also need to talk about safety and sourcing.

A lot of vitamins and dietary supplements people buy every day aren’t FDA approved for safety and effectiveness before they hit the market, so the phrase “not FDA approved” doesn’t automatically mean “bad.” But with peptides, especially compounded options, I care even more about where they come from.

I want provider review. I want a licensed pharmacy. I want clear instructions. I want quality standards. I want support if I have questions or concerns. I don’t want anyone playing mystery vial roulette because a website had sophisticated branding and a price that looked too good to be true.

So if you’ve been peptide curious but also slightly confused, suspicious, overwhelmed, or wondering if this is just another wellness trend with better packaging, I wrote the full beginner-friendly breakdown for you.

In the full post, I explain:
What peptides are
How peptides are different from amino acids and proteins
What peptides are used for in wellness
Why women over 40 are suddenly hearing about them
What “not FDA approved” actually means
How to think about peptide sourcing before you spend money on anything

You can read the full blog post 👉here👈

And honestly, if you’ve been seeing this topic everywhere and wondering if you missed the group text, you didn’t. The peptide conversation just got loud fast.

This is your starting point.

XOXO,
NIKI

PMOS. Perimenopause. Metabolic health. The real stuff. Not just “eat less, move more.”

ASK ME ANYTHING TRUSTED WELLNESS TOOLS
Not sure where to start? Take the free quiz and you’ll receive a personalized plan based on your unique goals.
FREE Peptide Quiz
P.S. Missed the previous editions of The Nurse’s RX?
↓ Catch up here ↓
READ PAST EDITIONS

↓ LET’S CONNECT ↓

FACEBOOK | INSTAGRAM | TIKTOK | YOUTUBE | SPOTIFY | GOODREADS


Let’s be clear about who I am (and who I’m not)

I’m a registered nurse and health coach who shares real, BS-free information about metabolic health, PCOS, perimenopause, and weight loss, because y’all deserve better than vague wellness fluff. But here’s what I need you to know: I am not YOUR nurse. Everything I share here is for educational purposes only. It is not medical advice, it’s not a diagnosis, and it doesn’t create a provider-patient relationship between us. Nothing here replaces the care of a licensed provider who actually knows your full health history. The opinions and content here are my own and do not reflect the views of my employer or the hospital where I work.

Scope of practice

As a nurse health coach, I can recommend over-the-counter products and supplements that may support your wellness goals. I don’t prescribe specific prescription medications. When it comes to GLP-1s and peptides, what I can do is talk about the science, what’s available, and what may be beneficial, so you can have an informed conversation with your licensed medical provider. The decision about what’s right for your body always belongs to you and your provider. Always consult your licensed provider before starting any prescription treatment. These statements have not been evaluated by the FDA. Products discussed are not intended to diagnose, treat, cure, or prevent any disease.

Transparency

I only recommend things I actually trust. Most are products I personally use, some are from partners whose clinical standards I believe in. I will always let you know when it’s something I haven’t tried personally. Some links in this email are affiliate links or part of brand partnerships, which means I may earn a commission at no extra cost to you. As an Amazon Associate, I earn from qualifying purchases.

Results + Testimonials

Any testimonials or results shared here reflect individual experiences only. Results are not guaranteed and will vary based on individual circumstances.

Read the full fine print at nicoleinscrubs.com/disclosure

No longer wish to receive these emails? UNSUBSCRIBE HERE

The Nurses’s RX no. 18: When your nervous system missed the memo

Happy Friday-Eve lol!

You know that thing where your brain understands that something is technically over, but your body absolutely didn’t get the memo?

Like the breakup happened. The hard conversation happened. The scary season happened. The job stress finally calmed down. The family chaos settled a little. Whatever it was, the event itself isn’t actively happening in front of you anymore, but your body is still walking around like it might start again any second.

That is such a weird place to be, because from the outside, you can look completely fine. You’re working. You’re answering texts. You’re showing up. You’re making dinner, folding laundry, pretending you didn’t just reread the same paragraph six times because your brain wandered into a side quest. Very normal adult woman behavior, obviously.

But internally? Different story.

Your chest feels tight for no clear reason. Your stomach drops when your phone buzzes. You’re jumpier than usual. Your thoughts are louder than they need to be. You’re tired, but not sleepy. You’re overstimulated, but also somehow bored. And if you’re an ADHD girlie like me, your brain already came with 900 tabs open, so now it’s 900 tabs open plus one emotional support tornado in the background.

Cute. Love that for us.

If any of that resonated… keep reading…

Selank is a compounded prescription nasal spray through EllieMD, and it’s a synthetic neuropeptide being studied for stress-response regulation, emotional balance, and cognitive function. It may help support the systems that help you feel steady, regulated, and mentally clear when your body has been running a little too “brace for impact.”

EllieMD Selank nasal spray bottle on a garden table with text highlighting stress and calm support, mental clarity, and mood and emotional balance.

And I want to be clear about what I’m not saying here. I’m not saying Selank treats anxiety, fixes heartbreak, replaces therapy, or magically makes life stop being life. If someone is in crisis, having severe symptoms, or feeling like they truly need mental health support, that is a provider conversation, full stop.

What I am saying is that there is a whole group of people who are not in full on crisis, but also don’t feel like themselves. They’re functional, but fried. They’re “fine,” but one unexpected noise away from becoming a feral raccoon in leggings. They don’t necessarily want to be sedated or checked out. They just want their internal alarm system to stop acting like every email, text, memory, or minor inconvenience is a threat.

Your stress response is supposed to activate when it needs to, then come back down when the threat is gone. But after a rough season, a big emotional hit, chronic stress, burnout, grief, or even just a long stretch of “I am handling everything because apparently that’s my assigned role in this lifetime,” sometimes that system feels like it gets stuck halfway on.

Not fully panicking. Not fully relaxed. Just hovering.

Selank is being studied for its potential role in supporting a calmer, more balanced stress response, emotional steadiness, and mental clarity without the goal being “knock me out so I can function less.”

EllieMD Selank nasal spray graphic explaining stress and calm support, mental clarity, and mood and emotional balance over a sunset silhouette.

And honestly, I think a lot of women, especially Xennial/Millennial women, are living in that middle ground. Not falling apart enough to call it a crisis, but not regulated enough to call it peace. We’re calling it “busy,” “stressed,” “overwhelmed,” “just a rough season,” or “I’m probably fine,” when sometimes what we mean is: my life moved on, but my body is still standing in the wreckage with a clipboard.

With EllieMD, Selank is reviewed by a licensed provider, and eligibility is determined by your individual health history and intake. It’s compounded, which means it is not FDA-approved, and the FDA does not evaluate compounded medications for safety, effectiveness, or quality before use. That is also why sourcing matters, because if I’m talking about a peptide nasal spray that interacts with brain and nervous system pathways, I am not interested in mystery-vendor roulette.

Here’s the question I’d start with:
Do you feel like you need more focus, or do you feel like you need your body to feel safe again?
Because Selank is more the 2nd one.
Not “make me a new person.”
Not “erase stress.”
More like: can we support the system that helps me feel steady while life is doing life?

If this feels like you Check out SELANK here

XOXO,
NIKI

PMOS. Perimenopause. Metabolic health. The real stuff. Not just “eat less, move more.”

ASK ME ANYTHING TRUSTED WELLNESS TOOLS
Not sure where to start? Take the free quiz and you’ll receive a personalized plan based on your unique goals.
FREE Peptide Quiz
P.S. Missed the previous editions of The Nurse’s RX?
↓ Catch up here ↓
READ PAST EDITIONS

↓ LET’S CONNECT ↓

FACEBOOK | INSTAGRAM | TIKTOK | YOUTUBE | SPOTIFY | GOODREADS


Let’s be clear about who I am (and who I’m not)

I’m a registered nurse and health coach who shares real, BS-free information about metabolic health, PCOS, perimenopause, and weight loss, because y’all deserve better than vague wellness fluff. But here’s what I need you to know: I am not YOUR nurse. Everything I share here is for educational purposes only. It is not medical advice, it’s not a diagnosis, and it doesn’t create a provider-patient relationship between us. Nothing here replaces the care of a licensed provider who actually knows your full health history. The opinions and content here are my own and do not reflect the views of my employer or the hospital where I work.

Scope of practice

As a nurse health coach, I can recommend over-the-counter products and supplements that may support your wellness goals. I don’t prescribe specific prescription medications. When it comes to GLP-1s and peptides, what I can do is talk about the science, what’s available, and what may be beneficial, so you can have an informed conversation with your licensed medical provider. The decision about what’s right for your body always belongs to you and your provider. Always consult your licensed provider before starting any prescription treatment. These statements have not been evaluated by the FDA. Products discussed are not intended to diagnose, treat, cure, or prevent any disease.

Transparency

I only recommend things I actually trust. Most are products I personally use, some are from partners whose clinical standards I believe in. I will always let you know when it’s something I haven’t tried personally. Some links in this email are affiliate links or part of brand partnerships, which means I may earn a commission at no extra cost to you. As an Amazon Associate, I earn from qualifying purchases.

Results + Testimonials

Any testimonials or results shared here reflect individual experiences only. Results are not guaranteed and will vary based on individual circumstances.

Read the full fine print at nicoleinscrubs.com/disclosure

No longer wish to receive these emails? UNSUBSCRIBE HERE

What Are Peptides? A Nurse Explains Why Everyone Is Suddenly Talking About Them

JUMP TO:: MEDICAL + AFFILIATE LINK DISCLOSURES


If you’ve been seeing people talk about peptides, peps, peppers, pepper gardens, or some weird version of the word peptide typed like it came from a ransom note, and you’ve been wondering what in the actual wellness internet is going on, you aren’t alone. It’s come to my attention that a lot of people are watching us talk about peptides like we have two heads because they have no clue what we’re even talking about or why they seem to be everywhere right now. And honestly? Fair.

Before I became more involved in the wellness side of things, I understood the basic science of peptides, but I didn’t fully understand how they were being used in longevity, skin health, energy support, recovery, metabolic health, or the newer wellness conversations happening online. I knew peptides existed in the body. I knew they mattered. But I wasn’t sitting around casually talking about peptide therapy over coffee like that was a normal Tuesday.

Why is everyone talking in code about peptides?

Before we even get into what peptides are, we need to talk about why you might see people calling them peps, peppers, pepper garden, 🌶️🌊, or some bizarre character version like Pɛp+ḷꝺΣ. It can look ridiculous from the outside, and to be clear, sometimes it IS ridiculous. But there’s a reason for it.

Social media platforms are not great at telling the difference between someone in the healthcare or wellness space providing legitimate educational content and someone selling gray market research peptides like they’re selling illegal drugs on the corner. So the people who are trying to talk about this responsibly often end up getting creative with language because platform filters can flag the topic before even getting to the context.

That doesn’t mean every coded post is trustworthy, and it definitely doesn’t mean every person using normal wording is unsafe. It just means the online peptide conversation has gotten weird because the internet made it weird. Shocking, I know.

So what are peptides?

Peptides are already in your body. They’re not some random wellness invention someone cooked up because they ran out of collagen powder to sell. Peptides are short chains of amino acids, and amino acids are the building blocks your body uses to make proteins.

Think of it like language. Amino acids are the letters. Peptides are short words or phrases made from those letters. Proteins are the longer sentences, paragraphs, or full instruction manuals made from those same letters arranged in more complex ways. That’s the simplest way to understand the relationship without turning this into a biochemistry class, which I promise nobody asked for today.

Peptides can act like messengers in the body. Depending on the peptide, that message may relate to skin health, collagen support, recovery, metabolic signaling, appetite signaling, cognitive function, tissue support, immune signaling, or cellular repair. That’s why the phrase “I take peptides” is honestly not very specific. It’s kind of like saying, “I take medication.” Okay… which one? For what? Through what route? Under whose guidance? For what goal?

What Are Peptides Used For? It Depends on the Peptide

This is one of the biggest things people miss when they first start hearing about peptides. Peptides aren’t all the same. They don’t all do the same job, and they aren’t all used for the same reason.

Some peptides are talked about for energy and cellular function. Some are being explored for skin, collagen, and tissue support. Some come up in conversations around muscle recovery, joint comfort, or workout recovery. Some are discussed in cognitive wellness. Others are connected to metabolic health and appetite signaling. Even within the same general category, two different peptides may work through completely different mechanisms in the body.

That’s why I don’t love when people ask, “What peptide should I take?” as if there is one universal answer. The better question is, “What am I trying to support, and what does my health history actually look like?” Because the peptide conversation for a woman who’s exhausted but sleeping fine may look very different from the peptide conversation for a woman dealing with skin changes, hair thinning, workout recovery issues, brain fog, or metabolic changes.

Why Women Over 40 Are Interested in Peptide Therapy for Energy, Skin, and Recovery

A lot of women aren’t peptide curious because they want another trendy wellness thing. They’re curious because something changed, and the old tools aren’t working the way they used to.

Maybe your skincare routine used to be enough, and now your skin still looks tired no matter how consistent you are. Maybe the Botox still smooths the lines, but it doesn’t fix the dullness, the skin laxity, the crepey texture, the volume loss, or the fact that your face still looks tired underneath it all. Maybe you’re working out, eating well, sleeping okay, and still dragging by 2pm. Maybe your recovery from workouts feels slower than it used to. Maybe your hair feels thinner, your body composition is changing, your brain feels foggy, or maybe your skin just doesn’t bounce back the way it used to. It’s annoying as hell because you’re still doing the skincare, the SPF, the appointments, all of it.

Then you go to your doctor, get the usual labs, and hear, “Everything looks fine.” Which is frustrating because “fine” does not explain why you feel exhausted, your skin looks different, your workouts take longer to recover from, and your body responds differently, even though your routine hasn’t changed.

That is where a lot of women start researching peptides. Not because they’re trying to become one of the bodybuilding biohacker bros. Not because they want to chase every shiny wellness trend. They’re trying to understand what’s happening under the surface and whether there are smarter options than just doing more of the same.

Are peptides FDA approved?

This is where we need to be specific, because “peptides are not FDA approved” is too broad.

Some FDA approved medications are peptide based or peptide related, like GLP-1s. But many of the peptides being discussed online in the wellness, longevity, recovery, skin, and performance spaces are not FDA approved medications. Compounded medications are also not FDA approved, which means the FDA does not evaluate them for safety, effectiveness, or quality before use.

That can sound scary, but it doesn’t automatically mean something is bad or unsafe. It means the details matter a lot. It means you need to care about who is evaluating you, where the medication is coming from, whether the pharmacy is licensed and regulated, whether testing is being used to verify quality, whether the instructions are clear, and whether there is actual support if you have questions or concerns.

This isn’t the category where I want anyone playing mystery vial roulette because a website had sophisticated branding and a price that looked too good to be true.

I know “not FDA approved” can sound scary, so let’s put that phrase in context. Dietary supplements, including many vitamins, minerals, and wellness products people buy every day, are also not FDA approved for safety and effectiveness before they hit the market. That doesn’t automatically make them bad, but it does mean the quality, sourcing, claims, testing, and company behind them matter.

The same general idea applies here, but with an important distinction: many peptides being discussed in wellness are not supplements. They are often compounded medications, which means they belong in a more medically guided lane. Compounded medications are not FDA approved, and that is exactly why provider review, a licensed pharmacy, clear instructions, and testing standards matter so much.

How to Choose a Peptide Source: Provider Review, Licensed Pharmacies, and Quality Testing

You can find almost anything online. That doesn’t mean you should put it in your body.

One of the biggest issues with peptides right now is that a lot of people don’t understand the difference between medically guided options and research grade gray market products. Some websites look polished. Some use medical language. Some have branding that feels legitimate at first glance. But clean branding doesn’t automatically mean provider oversight, proper pharmacy standards, clear dosing instructions, sterility, potency, purity, or support.

My green flag list is boring on purpose. I want licensed provider review. I want a licensed and regulated compounding pharmacy. I want third party testing for potency and purity. I want clear instructions. I want actual support if I have questions or concerns. I want transparency around what is compounded and what isn’t FDA approved. I want the process to feel medically guided, not like someone tossed you into the internet wilderness with a vial and a prayer.

That is the difference between “this exists online” and “this is a source I’d actually be comfortable putting my name next to.”

Why I Use EllieMD for Provider-Reviewed Peptide and Wellness Options

I personally use EllieMD, and I’m also a brand partner with them. That means yes, I may earn from qualifying orders through my link. It also means I’m putting my name, my nursing background, and my personal standards next to the company I’m choosing to talk about publicly.

The reason I talk about EllieMD isn’t because peptides are trendy. It’s because I wanted a source that checked the boxes I care about as a nurse and as a woman using some of these tools myself. And I wanted to have a trusted source to be able to recommend when I’m asked questions about peptides. Licensed provider review matters. A regulated pharmacy process matters. Clear instructions matter. Support matters. Quality standards matter. And not making people feel like they have to decode this entire category alone matters too.

For the woman who is already investing in skincare, med spa treatments, wellness tools, supplements, fitness, and better health, this is not about finding the cheapest option. It’s about asking whether the next investment actually makes sense, whether it is medically guided, and whether it is addressing the thing you’re actually trying to support.

Do peptides replace your doctor, labs, skincare, nutrition, or strength training?

No. And anyone making it sound that simple is already making me nervous.

Peptides are not a replacement for medical care. They are not a replacement for appropriate labs, nutrition, strength training, sleep, hormone evaluation, skincare, or an actual provider who understands your health history. They are one category of tools that may be worth discussing depending on your goals, medications, history, labs, budget, and what you are actually willing to do consistently.

The right conversation depends on the person. One woman may be looking at peptides because she’s sleeping fine but still exhausted. Another may be more focused on skin changes, collagen support, hair thinning, slower workout recovery, brain fog, libido, sleep, or metabolic support.

And for some people, peptides may not be the right fit at all. That is exactly why provider review matters.

That is why provider review matters. That is why your health history matters. And that is why I will never be the person telling everyone on the internet to take the same thing because one person had a good experience.

How to Know Which Peptide Might Fit Your Wellness Goals

If you’re new to peptides, I wouldn’t start with, “What is the best peptide?” I’d start with, “What am I actually trying to support?”

Are you looking for help with energy? Skin texture? Collagen support? Hair changes? Workout recovery? Brain fog? Metabolic health? Sleep? Libido? Joint comfort? Inflammation? Are you already taking medications or supplements? Do you have recent labs? Do you have a medical history that needs to be reviewed? Are you willing to give yourself injections, or do you need a nasal spray, capsule, or troche option? What are you actually going to use consistently?

Those questions matter more than whatever peptide is getting the most attention online this week.

Peptide Therapy for Women: What to Understand Before You Start

Peptides are not new. They aren’t magic internet dust. They’re not all the same. And they are definitely not something I’d recommend buying from a random research use only website because the pricing looked shockingly good.

Peptides are short chains of amino acids that can act like messengers in the body. Different peptides have different jobs, and some are being used or studied in wellness areas like energy, skin health, collagen support, recovery, tissue support, metabolic health, and cognitive function.

But the source matters. The provider matters. Your health history matters. Your goals matter. And whether this actually makes sense for you matters more than whatever the internet is screaming about this week.

If you want help narrowing down what might fit your goals, start with this peptide quiz. It will give you a personalized plan based on your unique goals and history. And if you get your results and you still want to talk through your options in more detail with me, I’m always available to help.


This post contains affiliate links and/or brand partnership content. I may earn a commission at no extra cost to you.

LET’S BE CLEAR ABOUT WHO I AM (AND WHO I’M NOT).

I’m a registered nurse and health coach who shares real, BS-free information about metabolic health, PCOS, perimenopause, and weight loss, because y’all deserve better than vague wellness fluff. But here’s what I need you to know: I am not YOUR nurse. Everything I share here is for educational purposes only. It is not medical advice, it’s not a diagnosis, and it doesn’t create a provider-patient relationship between us. Nothing on this site replaces the care of a licensed provider who actually knows your full health history. The opinions and content here are my own and do not reflect the views of my employer or the hospital where I work.

SCOPE OF PRACTICE.

As a nurse health coach, I can recommend over-the-counter products and supplements that may support your wellness goals. I don’t prescribe specific prescription medications. When it comes to GLP-1s and peptides, what I can do is talk about the science, what’s available, and what may be beneficial, so you can have an informed conversation with your licensed medical provider. The decision about what’s right for your body always belongs to you and your provider. Always consult your licensed provider before starting any prescription treatment — this is not something that should be DIY’d. These statements have not been evaluated by the FDA. Products discussed on this site are not intended to diagnose, treat, cure, or prevent any disease.

TRANSPARENCY.

I only recommend things I actually trust. Most are products I personally use, some are from partners whose clinical standards I believe in. I will always let you know when it’s something I haven’t tried personally. Some links on this site are affiliate links or part of brand partnerships, which means I may earn a commission at no extra cost to you. As an Amazon Associate I earn from qualifying purchases.

RESULTS + TESTIMONIALS.

Any testimonials or results shared on this site reflect individual experiences only. Results are not guaranteed and will vary based on individual circumstances.

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The Nurses’s RX no. 13: New onset eczema at 41 and what actually cleared it

The Nurse's RX newsletter header - Everything your doctor didn't have time to explain

Y’all. I have to tell you what happened.

Last summer, at 41 years old, I developed new-onset eczema.

On my EYELID. And under my eye. Of all the places on my body, it picked my face. Then, a few weeks later, a patch showed up on my neck like the party needed more guests.

I was furious. I was confused. I was LITERALLY doing everything right.

I was already using my Prequel skincare, which is formulated specifically for eczema- and rosacea-prone skin. When the flare wouldn’t quit, I stripped my routine down to the absolute bare bones. Topical hydrocortisone. Aquaphor. The most basic, boring, dermatologist-approved protocol you can do at home.

It would start to clear up… and then come right back. Over and over. For months.

Why would eczema suddenly show up in your 40s when you’ve never had it?

Turns out this is a real thing. And it’s way more common than anyone talks about.

Perimenopause does a number on your skin in ways most of us are never warned about. As estrogen starts to decline, your skin produces less oil, loses ceramides (the lipids that hold your skin barrier together), and the whole barrier function is compromised. Your skin microbiome shifts. Your immune response shifts. And the inflammation that your body used to handle quietly? Now it’s showing up on your face.

Research published in dermatology literature confirms that the drop in estrogen during perimenopause can trigger new-onset eczema or worsen existing eczema, even in women with no prior history. Skin gets thinner, drier, more reactive, and more easily inflamed.

So… cool. One more thing nobody tells you about your 40s.

But wait. Aren’t you on a GLP-1? Shouldn’t that be handling the inflammation?

This was literally my exact question. I’ve been on a GLP-1 for over two years. GLP-1s are known to reduce inflammation, even at low doses. So why was my face actively revolting?

GLP-1s reduce one type of inflammation, the metabolic kind. The kind driven by insulin resistance, visceral fat, and blood sugar dysfunction. And they do that really well.

But the inflammation driving perimenopausal skin changes is a different beast entirely. It’s hormonal. It’s local. It’s happening in my skin because my estrogen is dropping, my skin barrier is compromised, and my skin’s immune response is reacting to things it never used to.

GLP-1 is putting out the metabolic fire in my body. But the hormonal fire showing up in my skin needed something else.

Enter NAD+

Available in Injection or Nasal Spray through EllieMD

I started NAD+ injections last fall. I wasn’t taking them for my skin, honestly. I was taking them for energy, recovery, and general cellular function. You know, the perimenopausal brain fog. The skin improvement was surprising, but then when I thought about it, it made PERFECT SENSE.

But within a few weeks, I noticed my eczema was staying cleared up. Not in the “it’s better today, let’s see what happens tomorrow” way. In the actually gone way.

I added GHK-Cu later, which also has some skin benefits, but I want to be really clear. The eczema had already cleared before I added GHK-Cu. The NAD+ was doing the heavy lifting.

Hand holding CloveRX NAD+ and GHK-Cu injection vials prescribed through EllieMD telehealth with two insulin syringes for subcutaneous peptide injections
My skin stack from EllieMD.

And then I did what nurses do, which is make absolutely terrible patients. I got busy. I skipped a week. Then another one.

Guess what came back.

I went straight to my kitchen, pulled my vial out of the fridge, and took my injection. It cleared up again after a couple of weeks. Then I missed another week (I KNOW, I KNOW). Started seeing the early signs creeping back. Back to the kitchen I went. I also bumped up to tier 2 dosing, which is a higher dose, and the skin kept improving. Not getting worse. Which matters to me because it tells me my skin is responding to more NAD+, not less.

At this point, I am not messing around. NAD+ is in my toolbelt permanently.

But is there actual science behind this, or am I just seeing things?

I want to be honest with you here, because I am not trying to oversell anything.

Research on NAD+ and inflammatory skin conditions is still in its early stages. But what’s out there looks really promising.

NAD+ is a molecule every cell in your body uses to make energy and repair itself. When you’re young, you have a lot of it. As you age, levels drop. When NAD+ drops, your cells can’t handle stress as well, can’t repair damage as well, and can’t calm inflammation as well.

One 2023 study found that boosting NAD+ calmed down one of the main inflammation pathways (called Th17) that drives skin conditions like eczema and psoriasis. Basically, more NAD+ told the inflammation to settle down.

Another study on a form of NAD+ showed it reduced eczema symptoms, itching, and helped the skin barrier rebuild itself. It calmed the fire AND helped the wall.

And a big review from 2025 on a related form of vitamin B3 (nicotinamide) laid out why this whole family of molecules is already being used by dermatologists for eczema, rosacea, and other inflammatory skin issues.

So no. This is not me seeing things.

It’s me having a body that was inflamed, a skin barrier that was compromised, a hormonal transition nobody warned me was starting, and a cellular molecule (NAD+) that supports the exact repair and anti-inflammation work my skin needed.

It makes sense that it worked. It makes sense that when I stopped, it came back. And it makes sense that when I bumped up my dose, it kept improving.

CloveRX tirzepatide with glycine, NAD+, and GHK-Cu injection vials prescribed through EllieMD telehealth, arranged with insulin syringes and McKesson alcohol prep pads on a granite countertop
The full stack from EllieMD. Metabolic, cellular, skin. All working together.

What I want you to hear:

If you’re in your late 30s or 40s and something new is showing up on your skin, whether that’s eczema, rosacea flares, random dryness, or sensitivity you never had before, this is worth paying attention to. Your skin is telling you your hormones are shifting. That’s just physiology.

And if you’re already in the longevity and anti-aging conversation and you’re curious about NAD+ for energy, recovery, collagen, mitochondrial health… all the things… this is one more reason to pay attention. The skin benefits are real, even if the research is still catching up.

NAD+ is not a miracle cure. The research is preliminary. Anyone who tells you otherwise is selling you something.

But for me? It’s part of the stack now. PERMENANTLY

If you’re curious about NAD+ or want to actually talk to a provider about whether it’s something worth exploring for you, I use EllieMD for my telehealth. The physicians are real, the messaging is unlimited, and you can ask all the questions you need to ask before you start anything. (They work with CloveRX for compounding, which is the pharmacy that actually makes the peptides. Same consistent quality every single time, which is what I wanted when I made the switch.) With EllieMD you now have the option of NAD+ Injections or an NAD+ Nasal Spray (which I will probably try out with my next order).

As always, talk to your own provider, do your own research, and don’t start anything without understanding what it does and what it doesn’t do. I am a nurse, but I am not YOUR nurse, and this is not medical advice. It’s my story, the research I’ve pulled, and an invitation to look into it if it resonates.

Love you, mean it.

XOXO,
NIKI, RN

PCOS. Perimenopause. Metabolic health. The real stuff. Not just “eat less, move more.”

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Let’s be clear about who I am (and who I’m not)

I’m a registered nurse and health coach who shares real, BS-free information about metabolic health, PCOS, perimenopause, and weight loss, because y’all deserve better than vague wellness fluff. But here’s what I need you to know: I am not YOUR nurse. Everything I share here is for educational purposes only. It is not medical advice, it’s not a diagnosis, and it doesn’t create a provider-patient relationship between us. Nothing here replaces the care of a licensed provider who actually knows your full health history. The opinions and content here are my own and do not reflect the views of my employer or the hospital where I work.

Scope of practice

As a nurse health coach, I can recommend over-the-counter products and supplements that may support your wellness goals. I don’t prescribe specific prescription medications. When it comes to GLP-1s and peptides, what I can do is talk about the science, what’s available, and what may be beneficial, so you can have an informed conversation with your licensed medical provider. The decision about what’s right for your body always belongs to you and your provider. Always consult your licensed provider before starting any prescription treatment. These statements have not been evaluated by the FDA. Products discussed are not intended to diagnose, treat, cure, or prevent any disease.

Transparency

I only recommend things I actually trust. Most are products I personally use, some are from partners whose clinical standards I believe in. I will always let you know when it’s something I haven’t tried personally. Some links in this email are affiliate links or part of brand partnerships, which means I may earn a commission at no extra cost to you. As an Amazon Associate, I earn from qualifying purchases.

Results + Testimonials

Any testimonials or results shared here reflect individual experiences only. Results are not guaranteed and will vary based on individual circumstances.

Read the full fine print at nicoleinscrubs.com/disclosure

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NAD+ Injections Cleared My New-Onset Eczema at 41 (Perimenopause Skin Story + Research)

JUMP TO:: MEDICAL + AFFILIATE LINK DISCLOSURES


TL;DR: At 41, I developed new-onset eczema on my eyelid, under my eye, and later on my neck. I was already using eczema-approved skincare. Topical hydrocortisone and Aquaphor weren’t holding it. It would clear and come right back. NAD+ injections are what actually cleared it and kept it cleared. When I missed doses, it came back. When I resumed, it cleared again. Here’s the story, the research, and why this is more common in your 40s than anyone told you.

What New-Onset Eczema on the Face Looks Like at 41

New-onset eczema can show up in your 40s even if you’ve never had it before, and it often appears on the face, including sensitive areas like the eyelids. That’s exactly what happened to me.

I had never had eczema in my life. Not as a kid. Not as a teenager. Not as an adult.

And then last summer, it showed up on my EYELIDS. And under my eyes. Of all the places on my body, it picked my face. A few weeks later, a patch showed up on my neck.

I was furious. I was confused. I was LITERALLY doing everything right.

I was already using my Prequel skincare, which is specifically formulated for eczema and rosacea-prone skin. When the flare wouldn’t quit, I stripped my routine down to the absolute bare bones. Topical hydrocortisone. Aquaphor. The most basic, boring, dermatologist-approved protocol you can do at home.

It would start to clear up… and then come right back. Over and over. For months.

Why Does Eczema Suddenly Show Up in Your 40s?

Turns out this is a real thing. And it’s way more common than anyone talks about.

Perimenopause does a number on your skin in ways most of us are never warned about. As estrogen starts to decline, your skin produces less oil, loses ceramides (the lipids that hold your skin barrier together), and the whole barrier function is compromised. Your skin microbiome shifts. Your immune response shifts. And the inflammation that your body used to handle quietly? Now it’s showing up on your face.

Research published in dermatology literature confirms that the drop in estrogen during perimenopause can trigger new-onset eczema or worsen existing eczema, even in women with no prior history. Skin gets thinner, drier, more reactive, and more easily inflamed.

So… cool. One more thing nobody tells you about your 40s.

Do GLP-1s Reduce Skin Inflammation? Why Mine Didn’t Help My Eczema

This was literally my exact question. I’ve been on a GLP-1 for over two years. GLP-1s are known to reduce inflammation. So why was my face actively revolting?

GLP-1s reduce one type of inflammation, the metabolic kind. The kind driven by insulin resistance, visceral fat, and blood sugar dysfunction. And they do that really well, even at very low doses.

But the inflammation driving perimenopausal skin changes is a different beast entirely. It’s hormonal. It’s local. It’s happening in my skin because my estrogen is dropping, my skin barrier is compromised, and my immune response in my skin is reacting to things it never used to react to.

GLP-1 is putting out the metabolic fire in my body. But the hormonal fire showing up in my skin needed something else.

How NAD+ Injections Cleared My Perimenopausal Eczema

I started NAD+ injections (also available as a nasal spray)last fall. I wasn’t taking them for my skin, honestly. I was taking them for energy, recovery, and general cellular function. The skin improvement was not on my bingo card.

Hand holding a CloveRX NAD+ injection vial prescribed through EllieMD telehealth, 100mg/mL, 10mL multi-dose vial for subcutaneous use
My NAD+ injection, prescribed through EllieMD and compounded by CloveRX. This is the one that changed my skin.

But within a few weeks, I noticed my eczema was staying cleared up. Not in the “it’s better today, let’s see what happens tomorrow” way. In the actually gone way.

I added GHK-Cu later, which also has some skin benefits, but I want to be really clear. The eczema had already cleared before I added GHK-Cu. The NAD+ was doing the heavy lifting.

Hand holding CloveRX NAD+ and GHK-Cu injection vials prescribed through EllieMD telehealth with two insulin syringes for subcutaneous peptide injections
My skin stack from EllieMD.

What Happened When I Stopped Taking NAD+

If you stop taking NAD+, the anti-inflammatory benefits don’t stick around indefinitely. I found that out the hard way.

I did what nurses do, which is make absolutely terrible patients. I got busy. I skipped a week. Then another one. Then another…

Guess what came back. The damn eczema!!!!

I went straight to my kitchen, pulled my vial out of the fridge, and took my injection. It cleared up again. Then I missed another week (I KNOW, I KNOW). Started seeing the early signs creeping back. Back to the kitchen I went.

At this point, I am not messing around. NAD+ is in my toolbelt permanently.

Ellie MD NAD+ benefits infographic showing a vial surrounded by health benefits like energy, weight loss, anti-aging, and cognitive enhancement.
Ever feel like your “get up and go” just got up and left? NAD+ is basically a cellular deep clean that helps with energy and metabolic health.

Is There Actual Research Behind NAD+ and Eczema?

Yes, there is peer-reviewed research looking at NAD+ for inflammatory skin conditions, though the body of evidence is still early. I want to be honest with you here, because I am not trying to oversell anything.

Research on NAD+ and inflammatory skin conditions is still in its early stages. But what’s out there looks really promising.

NAD+ is a molecule every cell in your body uses to make energy and repair itself. When you’re young, you have a lot of it. As you age, levels drop. When NAD+ drops, your cells can’t handle stress as well, can’t repair damage as well, and can’t calm inflammation as well.

What the Peer-Reviewed Studies Show

A 2023 study in Cell Reports Medicine found that boosting NAD+ calmed down one of the main inflammation pathways (called Th17) that drives skin conditions like eczema and psoriasis. Basically, more NAD+ told the inflammation to settle down.

A 2022 study in International Immunopharmacology on a direct NAD+ precursor showed it reduced eczema-like symptoms, itching, and water loss through the skin. It also helped the skin barrier rebuild itself by boosting the proteins that hold it together. It calmed the fire AND helped the wall.

A 2023 paper on NAD+ and skin damage showed NAD+ administration decreased skin damage by reducing oxidative stress, inflammation, DNA damage, and cell death.

And a 2025 review in Medicina on a related form of vitamin B3 (nicotinamide, the precursor to NAD+) laid out why this whole family of molecules is already being used by dermatologists for atopic dermatitis, rosacea, and other inflammatory skin issues. It restores cellular energy, repairs DNA damage, and suppresses pro-inflammatory signals.

So no. This is not me seeing things.

It’s me having a body that was inflamed, a skin barrier that was compromised, a hormonal transition nobody warned me was starting, and a cellular molecule (NAD+) that supports the exact repair and anti-inflammation work my skin needed.

It makes sense that it worked. It makes sense that when I stopped, it came back. And it makes sense that when I bumped up my dose, it kept improving.

Who Should Consider NAD+ Supplements for Skin and Inflammation?

NAD+ isn’t for everyone, but there are two groups of women who tend to benefit most from this therapy.

If You’re in Your Late 30s or 40s and Something New Is Happening to Your Skin

If eczema, rosacea flares, random dryness, or sensitivity you never had before is suddenly showing up, this is worth paying attention to. Your skin is telling you your hormones are shifting. That’s just physiology.

If You’re Already Curious About NAD+ for Longevity and Anti-Aging

If you’re already in the longevity conversation and you’re looking at NAD+ for energy, recovery, collagen, mitochondrial health… all the things… the skin benefits are one more reason to pay attention. Even though the research is still catching up, what’s out there supports what a lot of women are already noticing.

CloveRX tirzepatide with glycine, NAD+, and GHK-Cu injection vials prescribed through EllieMD telehealth, arranged with insulin syringes and McKesson alcohol prep pads on a granite countertop
The full stack from EllieMD. Metabolic, cellular, skin. All working together.

What to Ask Your Provider About NAD+ Supplements

If you want to actually have an informed conversation with a provider instead of Googling at midnight (we’ve all been there), here are the questions I’d bring to the table.

  • Could my new skin issues be connected to perimenopause or hormonal changes?
  • What’s your take on NAD+ for inflammation and skin health?
  • Is subcutaneous NAD+ something you prescribe or would consider?
    • What about the Nasal Spray option?
  • Are there labs you’d want to check first, like hormone panels or inflammation markers?

If your current provider isn’t familiar with NAD+, peptides, or the perimenopause skin conversation, that doesn’t mean you’re out of options. I use EllieMD for my telehealth provider. The physicians are real, the messaging is unlimited, and you can ask every question you need to ask before you start anything. They work with CloveRX for compounding, which is the pharmacy that actually makes the peptides. Same consistent quality every single time. Made specifically for human use. Medical grade, not research grade. Tested for purity and potency. Triple purified for safety. And within the next month, they’ll be the first compounding pharmacy with all their peptide ingredients made in the USA rather than sourced internationally and compounded here. That’s what I wanted when I made the switch with my telehealth provider.

The Bottom Line on NAD+ for Eczema and Perimenopausal Skin

NAD+ is not a miracle cure. The research is preliminary. Anyone who tells you otherwise is selling you something.

But for me? It’s part of the stack now. Permanently.

If something new is showing up on your skin in your 40s and nothing you’re doing is making it stick, it’s worth looking into. Talk to your own provider. Do your own research. Don’t start anything without understanding what it does and what it doesn’t do. I am a nurse, but I am not YOUR nurse, and this is not medical advice. It’s my story, the research I’ve pulled, and an invitation to look into it if it resonates.

SEE IF NAD+ IS RIGHT FOR YOU

READ MORE ABOUT MY JOURNEY HERE


This post contains affiliate links and/or brand partnership content. I may earn a commission at no extra cost to you.

LET’S BE CLEAR ABOUT WHO I AM (AND WHO I’M NOT).

I’m a registered nurse and health coach who shares real, BS-free information about metabolic health, PCOS, perimenopause, and weight loss, because y’all deserve better than vague wellness fluff. But here’s what I need you to know: I am not YOUR nurse. Everything I share here is for educational purposes only. It is not medical advice, it’s not a diagnosis, and it doesn’t create a provider-patient relationship between us. Nothing on this site replaces the care of a licensed provider who actually knows your full health history. The opinions and content here are my own and do not reflect the views of my employer or the hospital where I work.

SCOPE OF PRACTICE.

As a nurse health coach, I can recommend over-the-counter products and supplements that may support your wellness goals. I don’t prescribe specific prescription medications. When it comes to GLP-1s and peptides, what I can do is talk about the science, what’s available, and what may be beneficial, so you can have an informed conversation with your licensed medical provider. The decision about what’s right for your body always belongs to you and your provider. Always consult your licensed provider before starting any prescription treatment — this is not something that should be DIY’d. These statements have not been evaluated by the FDA. Products discussed on this site are not intended to diagnose, treat, cure, or prevent any disease.

TRANSPARENCY.

I only recommend things I actually trust. Most are products I personally use, some are from partners whose clinical standards I believe in. I will always let you know when it’s something I haven’t tried personally. Some links on this site are affiliate links or part of brand partnerships, which means I may earn a commission at no extra cost to you. As an Amazon Associate I earn from qualifying purchases.

RESULTS + TESTIMONIALS.

Any testimonials or results shared on this site reflect individual experiences only. Results are not guaranteed and will vary based on individual circumstances.

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