I saw the new KLOW blend and was immediately like… hold up, wait a minute.
This has the GHK-Cu that I already LOOOOOVE, plus the BPC-157/TB-500 I had already been contemplating adding… ANNNND the KPV all in one?
Hell yes, sign me up.
If you’ve been around here for more than five minutes, you already know I’m not just casually curious about GHK-Cu. I’m on it. I love it. I have been very impressed by it. I’ve had more new baby hairs with GHK-Cu than I’ve seen with anything else I’ve tried in the last 10 years. My hair is growing faster, and I’ve also noticed improvement in the loose skin on my arms and neck.
So when I saw that EllieMD released a new compounded peptide blend with GHK-Cu in it, I wanted the details immediately. Then I realized it also includes BPC-157/TB-500, which I had already been looking at for recovery and tissue support, plus KPV, which I’ve been curious about for gut and inflammatory balance. It brings together several peptides I was already looking into separately, especially for the stuff so many of us start caring about when our bodies stop bouncing back like they used to…
Skin changes. Recovery. Gut support. Inflammation. Collagen. The “why do I feel like my body needs a system update?” era.
KLOW is one I would absolutely want to know about if you’ve been curious about peptides beyond GLP-1s, especially if you’re thinking more about long-term wellness, recovery, and supporting what your body is already trying to do.
CHECK OUT KLOW HERE
If you’ve clicked a link and can’t see KLOW, it’s because it’s one that requires Exclusive Access to view. Just sign in with your free EllieMD account
OR CREATE ONE HERE
XOXO, NIKI
PCOS. Perimenopause. Metabolic health. The real stuff. Not just “eat less, move more.”
I’m a registered nurse and health coach who shares real, BS-free information about metabolic health, PCOS, perimenopause, and weight loss, because y’all deserve better than vague wellness fluff. But here’s what I need you to know: I am not YOUR nurse. Everything I share here is for educational purposes only. It is not medical advice, it’s not a diagnosis, and it doesn’t create a provider-patient relationship between us. Nothing here replaces the care of a licensed provider who actually knows your full health history. The opinions and content here are my own and do not reflect the views of my employer or the hospital where I work.
Scope of practice
As a nurse health coach, I can recommend over-the-counter products and supplements that may support your wellness goals. I don’t prescribe specific prescription medications. When it comes to GLP-1s and peptides, what I can do is talk about the science, what’s available, and what may be beneficial, so you can have an informed conversation with your licensed medical provider. The decision about what’s right for your body always belongs to you and your provider. Always consult your licensed provider before starting any prescription treatment. These statements have not been evaluated by the FDA. Products discussed are not intended to diagnose, treat, cure, or prevent any disease.
Transparency
I only recommend things I actually trust. Most are products I personally use, some are from partners whose clinical standards I believe in. I will always let you know when it’s something I haven’t tried personally. Some links in this email are affiliate links or part of brand partnerships, which means I may earn a commission at no extra cost to you. As an Amazon Associate, I earn from qualifying purchases.
Results + Testimonials
Any testimonials or results shared here reflect individual experiences only. Results are not guaranteed and will vary based on individual circumstances.
Last summer, at 41 years old, I developed new-onset eczema.
On my EYELID. And under my eye. Of all the places on my body, it picked my face. Then, a few weeks later, a patch showed up on my neck like the party needed more guests.
I was furious. I was confused. I was LITERALLY doing everything right.
It would start to clear up… and then come right back. Over and over. For months.
Why would eczema suddenly show up in your 40s when you’ve never had it?
Turns out this is a real thing. And it’s way more common than anyone talks about.
Perimenopause does a number on your skin in ways most of us are never warned about. As estrogen starts to decline, your skin produces less oil, loses ceramides (the lipids that hold your skin barrier together), and the whole barrier function is compromised. Your skin microbiome shifts. Your immune response shifts. And the inflammation that your body used to handle quietly? Now it’s showing up on your face.
Research published in dermatology literature confirms that the drop in estrogen during perimenopause can trigger new-onset eczema or worsen existing eczema, even in women with no prior history. Skin gets thinner, drier, more reactive, and more easily inflamed.
So… cool. One more thing nobody tells you about your 40s.
But wait. Aren’t you on a GLP-1? Shouldn’t that be handling the inflammation?
GLP-1s reduce one type of inflammation, the metabolic kind. The kind driven by insulin resistance, visceral fat, and blood sugar dysfunction. And they do that really well.
But the inflammation driving perimenopausal skin changes is a different beast entirely. It’s hormonal. It’s local. It’s happening in my skin because my estrogen is dropping, my skin barrier is compromised, and my skin’s immune response is reacting to things it never used to.
GLP-1 is putting out the metabolic fire in my body. But the hormonal fire showing up in my skin needed something else.
Enter NAD+
Available in Injection or Nasal Spray through EllieMD
I started NAD+ injections last fall. I wasn’t taking them for my skin, honestly. I was taking them for energy, recovery, and general cellular function. You know, the perimenopausal brain fog. The skin improvement was surprising, but then when I thought about it, it made PERFECT SENSE.
But within a few weeks, I noticed my eczema was staying cleared up. Not in the “it’s better today, let’s see what happens tomorrow” way. In the actually gone way.
And then I did what nurses do, which is make absolutely terrible patients. I got busy. I skipped a week. Then another one.
Guess what came back.
I went straight to my kitchen, pulled my vial out of the fridge, and took my injection. It cleared up again after a couple of weeks. Then I missed another week (I KNOW, I KNOW). Started seeing the early signs creeping back. Back to the kitchen I went. I also bumped up to tier 2 dosing, which is a higher dose, and the skin kept improving. Not getting worse. Which matters to me because it tells me my skin is responding to more NAD+, not less.
But is there actual science behind this, or am I just seeing things?
I want to be honest with you here, because I am not trying to oversell anything.
Research on NAD+ and inflammatory skin conditions is still in its early stages. But what’s out there looks really promising.
NAD+ is a molecule every cell in your body uses to make energy and repair itself. When you’re young, you have a lot of it. As you age, levels drop. When NAD+ drops, your cells can’t handle stress as well, can’t repair damage as well, and can’t calm inflammation as well.
One 2023 study found that boosting NAD+ calmed down one of the main inflammation pathways (called Th17) that drives skin conditions like eczema and psoriasis. Basically, more NAD+ told the inflammation to settle down.
Another study on a form of NAD+ showed it reduced eczema symptoms, itching, and helped the skin barrier rebuild itself. It calmed the fire AND helped the wall.
And a big review from 2025 on a related form of vitamin B3 (nicotinamide) laid out why this whole family of molecules is already being used by dermatologists for eczema, rosacea, and other inflammatory skin issues.
So no. This is not me seeing things.
It’s me having a body that was inflamed, a skin barrier that was compromised, a hormonal transition nobody warned me was starting, and a cellular molecule (NAD+) that supports the exact repair and anti-inflammation work my skin needed.
It makes sense that it worked. It makes sense that when I stopped, it came back. And it makes sense that when I bumped up my dose, it kept improving.
The full stack from EllieMD. Metabolic, cellular, skin. All working together.
What I want you to hear:
If you’re in your late 30s or 40s and something new is showing up on your skin, whether that’s eczema, rosacea flares, random dryness, or sensitivity you never had before, this is worth paying attention to. Your skin is telling you your hormones are shifting. That’s just physiology.
And if you’re already in the longevity and anti-aging conversation and you’re curious about NAD+ for energy, recovery, collagen, mitochondrial health… all the things… this is one more reason to pay attention. The skin benefits are real, even if the research is still catching up.
NAD+ is not a miracle cure. The research is preliminary. Anyone who tells you otherwise is selling you something.
But for me? It’s part of the stack now. PERMENANTLY
If you’re curious about NAD+ or want to actually talk to a provider about whether it’s something worth exploring for you, I use EllieMD for my telehealth. The physicians are real, the messaging is unlimited, and you can ask all the questions you need to ask before you start anything. (They work with CloveRX for compounding, which is the pharmacy that actually makes the peptides. Same consistent quality every single time, which is what I wanted when I made the switch.) With EllieMD you now have the option of NAD+ Injections or an NAD+ Nasal Spray (which I will probably try out with my next order).
As always, talk to your own provider, do your own research, and don’t start anything without understanding what it does and what it doesn’t do. I am a nurse, but I am not YOUR nurse, and this is not medical advice. It’s my story, the research I’ve pulled, and an invitation to look into it if it resonates.
Love you, mean it.
XOXO, NIKI, RN
PCOS. Perimenopause. Metabolic health. The real stuff. Not just “eat less, move more.”
I’m a registered nurse and health coach who shares real, BS-free information about metabolic health, PCOS, perimenopause, and weight loss, because y’all deserve better than vague wellness fluff. But here’s what I need you to know: I am not YOUR nurse. Everything I share here is for educational purposes only. It is not medical advice, it’s not a diagnosis, and it doesn’t create a provider-patient relationship between us. Nothing here replaces the care of a licensed provider who actually knows your full health history. The opinions and content here are my own and do not reflect the views of my employer or the hospital where I work.
Scope of practice
As a nurse health coach, I can recommend over-the-counter products and supplements that may support your wellness goals. I don’t prescribe specific prescription medications. When it comes to GLP-1s and peptides, what I can do is talk about the science, what’s available, and what may be beneficial, so you can have an informed conversation with your licensed medical provider. The decision about what’s right for your body always belongs to you and your provider. Always consult your licensed provider before starting any prescription treatment. These statements have not been evaluated by the FDA. Products discussed are not intended to diagnose, treat, cure, or prevent any disease.
Transparency
I only recommend things I actually trust. Most are products I personally use, some are from partners whose clinical standards I believe in. I will always let you know when it’s something I haven’t tried personally. Some links in this email are affiliate links or part of brand partnerships, which means I may earn a commission at no extra cost to you. As an Amazon Associate, I earn from qualifying purchases.
Results + Testimonials
Any testimonials or results shared here reflect individual experiences only. Results are not guaranteed and will vary based on individual circumstances.
I need to explain something about sleep that nobody told me for most of my life. And I’m willing to bet nobody told you either.
I’ve been a night owl since second grade. Every time my schedule forced me onto days, I reached for melatonin, thinking it would help me adjust. It got me to sleep. I still woke up every single time feeling like I hadn’t slept at all.
For years, I thought my body was just bad at this. Turns out the problem was never falling asleep. The problem was what was (or wasn’t) happening AFTER.
Here’s your nurse lesson for the day.
Your sleep has stages. Stage 3, also called deep sleep, is where your body does the actual overnight repair work. Your brain files away memories. Your immune system does its thing. Your hormones get regulated. Tissue gets repaired. ALL of it happens in deep sleep.
And here’s what your doctor probably never connected for you… deep sleep is the FIRST stage to get destroyed by stress, hormonal shifts, and age. Perimenopause? Your sleep architecture starts changing before you even realize what’s happening. You can sleep 8 hours and barely touch the deep stage. You were in the pool all night, but you never went below the surface.
Melatonin doesn’t fix this. Melatonin tells your body WHEN to sleep. That’s it. It puts up the “closed” sign on the store. But whether the cleaning crew actually shows up to do the repair work? Melatonin has nothing to do with that.
The sign said closed. The cleaning crew never came.
There’s also a handoff that’s supposed to happen every night between your stress system and your sleep system. They take turns. Stress runs the day, then clocks out so sleep can take over. When that handoff breaks down, you get that “tired but wired” feeling… exhausted, but your brain won’t stop running the list. That’s not a personality trait. That’s a broken shift change inside your body.
DSIP (Delta Sleep-Inducing Peptide) is being studied for BOTH of these things. The depth of your sleep AND the stress handoff. It’s been researched for over 40 years. It’s not a sedative. No morning fog. No dependency. It works with your body’s own systems instead of overriding them.
I’m about to be forced onto day shift for three months (I KNOW). Then, a few days later, EllieMD dropped DSIP. The TIMING. I dug into the research and… this sounds like exactly what I need right now. You know I’ve already ordered it! I’ll keep you updated on how it goes.
I wrote a full breakdown on the blog. What DSIP is, how it’s different from melatonin, what deep sleep actually does for your body, and who this might help most.t it with real physician oversight.
If you’ve been sleeping “enough” hours and STILL waking up exhausted… this post explains WHY. And that answer alone is worth the click.
Not sure where to start? Take my free quiz and I’ll send you a custom plan.
WHAT’S RIGHT FOR MY BODY?
P.S. Missed the previous editions of The Nurse’s RX? ↓ Catch up here ↓
READ PAST EDITIONS
↓ LET’S CONNECT ↓
Let’s be clear about who I am (and who I’m not)
I’m a registered nurse and health coach who shares real, BS-free information about metabolic health, PCOS, perimenopause, and weight loss, because y’all deserve better than vague wellness fluff. But here’s what I need you to know: I am not YOUR nurse. Everything I share here is for educational purposes only. It is not medical advice, it’s not a diagnosis, and it doesn’t create a provider-patient relationship between us. Nothing here replaces the care of a licensed provider who actually knows your full health history. The opinions and content here are my own and do not reflect the views of my employer or the hospital where I work.
Scope of practice
As a nurse health coach, I can recommend over-the-counter products and supplements that may support your wellness goals. I don’t prescribe specific prescription medications. When it comes to GLP-1s and peptides, what I can do is talk about the science, what’s available, and what may be beneficial, so you can have an informed conversation with your licensed medical provider. The decision about what’s right for your body always belongs to you and your provider. Always consult your licensed provider before starting any prescription treatment. These statements have not been evaluated by the FDA. Products discussed are not intended to diagnose, treat, cure, or prevent any disease.
Transparency
I only recommend things I actually trust. Most are products I personally use, some are from partners whose clinical standards I believe in. I will always let you know when it’s something I haven’t tried personally. Some links in this email are affiliate links or part of brand partnerships, which means I may earn a commission at no extra cost to you. As an Amazon Associate, I earn from qualifying purchases.
Results + Testimonials
Any testimonials or results shared here reflect individual experiences only. Results are not guaranteed and will vary based on individual circumstances.
TL;DR: At 41, I developed new-onset eczema on my eyelid, under my eye, and later on my neck. I was already using eczema-approved skincare. Topical hydrocortisone and Aquaphor weren’t holding it. It would clear and come right back. NAD+ injections are what actually cleared it and kept it cleared. When I missed doses, it came back. When I resumed, it cleared again. Here’s the story, the research, and why this is more common in your 40s than anyone told you.
What New-Onset Eczema on the Face Looks Like at 41
New-onset eczema can show up in your 40s even if you’ve never had it before, and it often appears on the face, including sensitive areas like the eyelids. That’s exactly what happened to me.
I had never had eczema in my life. Not as a kid. Not as a teenager. Not as an adult.
And then last summer, it showed up on my EYELIDS. And under my eyes. Of all the places on my body, it picked my face. A few weeks later, a patch showed up on my neck.
I was furious. I was confused. I was LITERALLY doing everything right.
It would start to clear up… and then come right back. Over and over. For months.
Why Does Eczema Suddenly Show Up in Your 40s?
Turns out this is a real thing. And it’s way more common than anyone talks about.
Perimenopause does a number on your skin in ways most of us are never warned about. As estrogen starts to decline, your skin produces less oil, loses ceramides (the lipids that hold your skin barrier together), and the whole barrier function is compromised. Your skin microbiome shifts. Your immune response shifts. And the inflammation that your body used to handle quietly? Now it’s showing up on your face.
Research published in dermatology literature confirms that the drop in estrogen during perimenopause can trigger new-onset eczema or worsen existing eczema, even in women with no prior history. Skin gets thinner, drier, more reactive, and more easily inflamed.
So… cool. One more thing nobody tells you about your 40s.
Do GLP-1s Reduce Skin Inflammation? Why Mine Didn’t Help My Eczema
This was literally my exact question. I’ve been on a GLP-1 for over two years. GLP-1s are known to reduce inflammation. So why was my face actively revolting?
GLP-1s reduce one type of inflammation, the metabolic kind. The kind driven by insulin resistance, visceral fat, and blood sugar dysfunction. And they do that really well, even at very low doses.
But the inflammation driving perimenopausal skin changes is a different beast entirely. It’s hormonal. It’s local. It’s happening in my skin because my estrogen is dropping, my skin barrier is compromised, and my immune response in my skin is reacting to things it never used to react to.
GLP-1 is putting out the metabolic fire in my body. But the hormonal fire showing up in my skin needed something else.
How NAD+ Injections Cleared My Perimenopausal Eczema
I started NAD+ injections (also available as a nasal spray)last fall. I wasn’t taking them for my skin, honestly. I was taking them for energy, recovery, and general cellular function. The skin improvement was not on my bingo card.
My NAD+ injection, prescribed through EllieMD and compounded by CloveRX. This is the one that changed my skin.
But within a few weeks, I noticed my eczema was staying cleared up. Not in the “it’s better today, let’s see what happens tomorrow” way. In the actually gone way.
I added GHK-Cu later, which also has some skin benefits, but I want to be really clear. The eczema had already cleared before I added GHK-Cu. The NAD+ was doing the heavy lifting.
My skin stack from EllieMD.
What Happened When I Stopped Taking NAD+
If you stop taking NAD+, the anti-inflammatory benefits don’t stick around indefinitely. I found that out the hard way.
I did what nurses do, which is make absolutely terrible patients. I got busy. I skipped a week. Then another one. Then another…
Guess what came back. The damn eczema!!!!
I went straight to my kitchen, pulled my vial out of the fridge, and took my injection. It cleared up again. Then I missed another week (I KNOW, I KNOW). Started seeing the early signs creeping back. Back to the kitchen I went.
Ever feel like your “get up and go” just got up and left? NAD+ is basically a cellular deep clean that helps with energy and metabolic health.
Is There Actual Research Behind NAD+ and Eczema?
Yes, there is peer-reviewed research looking at NAD+ for inflammatory skin conditions, though the body of evidence is still early. I want to be honest with you here, because I am not trying to oversell anything.
Research on NAD+ and inflammatory skin conditions is still in its early stages. But what’s out there looks really promising.
NAD+ is a molecule every cell in your body uses to make energy and repair itself. When you’re young, you have a lot of it. As you age, levels drop. When NAD+ drops, your cells can’t handle stress as well, can’t repair damage as well, and can’t calm inflammation as well.
What the Peer-Reviewed Studies Show
A 2023 study in Cell Reports Medicine found that boosting NAD+ calmed down one of the main inflammation pathways (called Th17) that drives skin conditions like eczema and psoriasis. Basically, more NAD+ told the inflammation to settle down.
A 2022 study in International Immunopharmacology on a direct NAD+ precursor showed it reduced eczema-like symptoms, itching, and water loss through the skin. It also helped the skin barrier rebuild itself by boosting the proteins that hold it together. It calmed the fire AND helped the wall.
A 2023 paper on NAD+ and skin damage showed NAD+ administration decreased skin damage by reducing oxidative stress, inflammation, DNA damage, and cell death.
And a 2025 review in Medicina on a related form of vitamin B3 (nicotinamide, the precursor to NAD+) laid out why this whole family of molecules is already being used by dermatologists for atopic dermatitis, rosacea, and other inflammatory skin issues. It restores cellular energy, repairs DNA damage, and suppresses pro-inflammatory signals.
So no. This is not me seeing things.
It’s me having a body that was inflamed, a skin barrier that was compromised, a hormonal transition nobody warned me was starting, and a cellular molecule (NAD+) that supports the exact repair and anti-inflammation work my skin needed.
It makes sense that it worked. It makes sense that when I stopped, it came back. And it makes sense that when I bumped up my dose, it kept improving.
Who Should Consider NAD+ Supplements for Skin and Inflammation?
NAD+ isn’t for everyone, but there are two groups of women who tend to benefit most from this therapy.
If You’re in Your Late 30s or 40s and Something New Is Happening to Your Skin
If eczema, rosacea flares, random dryness, or sensitivity you never had before is suddenly showing up, this is worth paying attention to. Your skin is telling you your hormones are shifting. That’s just physiology.
If You’re Already Curious About NAD+ for Longevity and Anti-Aging
If you’re already in the longevity conversation and you’re looking at NAD+ for energy, recovery, collagen, mitochondrial health… all the things… the skin benefits are one more reason to pay attention. Even though the research is still catching up, what’s out there supports what a lot of women are already noticing.
The full stack from EllieMD. Metabolic, cellular, skin. All working together.
What to Ask Your Provider About NAD+ Supplements
If you want to actually have an informed conversation with a provider instead of Googling at midnight (we’ve all been there), here are the questions I’d bring to the table.
Could my new skin issues be connected to perimenopause or hormonal changes?
What’s your take on NAD+ for inflammation and skin health?
Is subcutaneous NAD+ something you prescribe or would consider?
What about the Nasal Spray option?
Are there labs you’d want to check first, like hormone panels or inflammation markers?
If your current provider isn’t familiar with NAD+, peptides, or the perimenopause skin conversation, that doesn’t mean you’re out of options. I use EllieMD for my telehealth provider. The physicians are real, the messaging is unlimited, and you can ask every question you need to ask before you start anything. They work with CloveRX for compounding, which is the pharmacy that actually makes the peptides. Same consistent quality every single time. Made specifically for human use. Medical grade, not research grade. Tested for purity and potency. Triple purified for safety. And within the next month, they’ll be the first compounding pharmacy with all their peptide ingredients made in the USA rather than sourced internationally and compounded here. That’s what I wanted when I made the switch with my telehealth provider.
The Bottom Line on NAD+ for Eczema and Perimenopausal Skin
NAD+ is not a miracle cure. The research is preliminary. Anyone who tells you otherwise is selling you something.
But for me? It’s part of the stack now. Permanently.
If something new is showing up on your skin in your 40s and nothing you’re doing is making it stick, it’s worth looking into. Talk to your own provider. Do your own research. Don’t start anything without understanding what it does and what it doesn’t do. I am a nurse, but I am not YOUR nurse, and this is not medical advice. It’s my story, the research I’ve pulled, and an invitation to look into it if it resonates.
This post contains affiliate links and/or brand partnership content. I may earn a commission at no extra cost to you.
LET’S BE CLEAR ABOUT WHO I AM (AND WHO I’M NOT).
I’m a registered nurse and health coach who shares real, BS-free information about metabolic health, PCOS, perimenopause, and weight loss, because y’all deserve better than vague wellness fluff. But here’s what I need you to know: I am not YOUR nurse. Everything I share here is for educational purposes only. It is not medical advice, it’s not a diagnosis, and it doesn’t create a provider-patient relationship between us. Nothing on this site replaces the care of a licensed provider who actually knows your full health history. The opinions and content here are my own and do not reflect the views of my employer or the hospital where I work.
SCOPE OF PRACTICE.
As a nurse health coach, I can recommend over-the-counter products and supplements that may support your wellness goals. I don’t prescribe specific prescription medications. When it comes to GLP-1s and peptides, what I can do is talk about the science, what’s available, and what may be beneficial, so you can have an informed conversation with your licensed medical provider. The decision about what’s right for your body always belongs to you and your provider. Always consult your licensed provider before starting any prescription treatment — this is not something that should be DIY’d. These statements have not been evaluated by the FDA. Products discussed on this site are not intended to diagnose, treat, cure, or prevent any disease.
TRANSPARENCY.
I only recommend things I actually trust. Most are products I personally use, some are from partners whose clinical standards I believe in. I will always let you know when it’s something I haven’t tried personally. Some links on this site are affiliate links or part of brand partnerships, which means I may earn a commission at no extra cost to you. As an Amazon Associate I earn from qualifying purchases.
RESULTS + TESTIMONIALS.
Any testimonials or results shared on this site reflect individual experiences only. Results are not guaranteed and will vary based on individual circumstances.
Before we even get into glycine, we have to talk about amino acids.
And don’t worry, I’m not giving you a textbook. I’m giving you the way I break things down when someone looks at me like their brain just froze and says “explain that again… slower.”
Glycine as an oral amino acid supplement, often used for sleep and recovery support.
Amino acids are your body’s tiny building blocks. Picture them like the individual beads on a long necklace. Each bead matters. The necklace only works when all the beads are there and in the right order. That’s how proteins work in your body. They’re these long chains built from amino acids, and proteins run pretty much everything your body needs to do.
Hormones. Healing. Muscle repair. Brain chemicals that decide whether you’re calm or jittery. Skin, joints, immune support. All of it starts with these little building block beads.
Glycine is one of those beads. It’s small but seriously important.
It helps your nervous system settle so you can move into deeper, more restorative sleep. It plays a role in collagen. It supports recovery. And it’s one of those quiet contributors you don’t notice until it’s finally there and you start feeling steadier.
Now here’s where the weekly injection part comes in.
Compounded GLP-1/GIP medication with glycine added for supportive benefits.
When glycine is added to your GLP1 or GLP1 GIP injection, it’s not something you take “as needed.” You’re not grabbing it on nights when you can’t sleep or tossing it in like a supplement. It’s built into your once a week routine, giving your body a consistent, predictable level to work with. And that consistency is exactly what makes it helpful.
If you’re in maintenance, glycine can help keep you regulated. Better sleep. Smoother recovery. A calmer nervous system. Those pieces matter a lot when your goal is staying steady instead of losing.
If you’re in active weight loss, glycine still pulls its weight. Your body is adjusting, repairing, rebuilding, and shifting behind the scenes. Better sleep and better recovery help your system handle all of that without feeling drained or overstressed. Glycine basically supports the “invisible” work that happens during this phase.
So no matter where you are in your journey, glycine isn’t dramatic or flashy. It’s just steady support that shows up week after week, working quietly in the background while your body handles the rest.
Next up, we can dive into L Carnitine or NAD. Whichever one you want next, I’ve got you.
This post contains affiliate links and/or brand partnership content. I may earn a commission at no extra cost to you.
LET’S BE CLEAR ABOUT WHO I AM (AND WHO I’M NOT).
I’m a registered nurse and health coach who shares real, BS-free information about metabolic health, PCOS, perimenopause, and weight loss, because y’all deserve better than vague wellness fluff. But here’s what I need you to know: I am not YOUR nurse. Everything I share here is for educational purposes only. It is not medical advice, it’s not a diagnosis, and it doesn’t create a provider-patient relationship between us. Nothing on this site replaces the care of a licensed provider who actually knows your full health history. The opinions and content here are my own and do not reflect the views of my employer or the hospital where I work.
SCOPE OF PRACTICE.
As a nurse health coach, I can recommend over-the-counter products and supplements that may support your wellness goals. I don’t prescribe specific prescription medications. When it comes to GLP-1s and peptides, what I can do is talk about the science, what’s available, and what may be beneficial, so you can have an informed conversation with your licensed medical provider. The decision about what’s right for your body always belongs to you and your provider. Always consult your licensed provider before starting any prescription treatment — this is not something that should be DIY’d. These statements have not been evaluated by the FDA. Products discussed on this site are not intended to diagnose, treat, cure, or prevent any disease.
TRANSPARENCY.
I only recommend things I actually trust. Most are products I personally use, some are from partners whose clinical standards I believe in. I will always let you know when it’s something I haven’t tried personally. Some links on this site are affiliate links or part of brand partnerships, which means I may earn a commission at no extra cost to you. As an Amazon Associate I earn from qualifying purchases.
RESULTS + TESTIMONIALS.
Any testimonials or results shared on this site reflect individual experiences only. Results are not guaranteed and will vary based on individual circumstances.
You ever hit that point where coffee feels like emotional support at this stage, but the energy part packed up and left? Same.
That’s when I learned about NAD+. It’s basically the MVP molecule that helps your body turn food into actual, usable energy. Think of it like the little spark plug inside your cells that keeps everything running — focus, metabolism, mood, all of it.
Ever feel like your “get up and go” just got up and left? NAD+ is basically a cellular deep clean that helps with energy and metabolic health.
But here’s the kicker. NAD+ levels drop as we age, stress, or live on caffeine and vibes (guilty). Supporting those levels can help your body’s natural energy process stay on track. For me, it’s been the difference between dragging and doing.
Not a miracle fix, just a subtle, steady kind of clarity that coffee wishes it could give.
Professional Disclosure: I provide BS-free metabolic education as a registered nurse and health coach for women navigating PCOS, perimenopause, and stubborn weight loss. While I share evidence-based research and nurse-informed support, please remember that I am not your nurse. The content shared here is for educational purposes only. It does not constitute medical advice, diagnosis, or treatment, and it does not establish a provider-patient relationship. Nothing on this site is a substitute for care from a licensed provider who knows your full health history. All opinions and content shared on this platform are my own and do not reflect the views or endorsements of my employer or the hospital where I am employed.
Scope of Practice and FDA: Per professional coaching guidelines, I may recommend over the counter (OTC) medications or supplements to support your wellness goals. However, I do not prescribe or recommend specific prescription medications. For prescription options, including GLP-1 tools, my role is to help you understand the available science so you can have an informed discussion with your licensed healthcare provider. These statements have not been evaluated by the Food and Drug Administration. Products discussed are not intended to diagnose, treat, cure, or prevent any disease, and medical treatments require professional oversight.
Trust and Transparency: I only recommend products I trust. Most are items I use personally, while others are shared based on my professional trust in the clinical standards of partners like Ellie MD. Some links are affiliate links or part of brand partnerships, which means I may earn a commission at no extra cost to you. As an Amazon Associate I earn from qualifying purchases.
Let’s be real for a second. If you looked down and saw blue or blue-green pee in the toilet, you’d probably freak out just a little, right? But what if I told you that “blue pee” is actually the latest buzz in the wellness world for kicking brain fog to the curb?
If you’ve been feeling like your brain is stuck in a permanent mid-afternoon slump, or if perimenopause has invited “brain fog” to live in your head rent-free, you’re going to want to read this.
What is Methylene Blue? (And no, it’s not a TikTok trend)
While it might be trending on social media, Methylene Blue is actually the “OG” of medicine. It’s a pharmaceutical-grade compounded dye that has been used by doctors and hospitals for over 150 years.
Methylene blue is being studied for its potential role in supporting cognitive function, cellular energy, and mitochondrial health.
The “Blue Pee” Mystery Solved
First things first: the blue pee. It’s totally normal! It’s just a sign that your body is processing the Methylene Blue exactly how it should. Your system takes what it needs for cellular energy and flushes out the rest.
Pro-Tip: If your 💩 turns blue, that’s a different story. That’s a “call your provider” moment because it means your body isn’t breaking it down quite right.
Why Women are Reaching for Methylene Blue for Brain Fog
If you are in the perimenopause trenches, you know that energy isn’t exactly predictable anymore. One minute you’re fine, the next you’re hitting a wall that even an Alani can’t fix.
Methylene Blue is being studied for its potential to support:
Mental Clarity: Helping you find your keys (and your train of thought).
Physical Energy: Boosting how your cells turn oxygen into fuel.
Cognitive Function: Supporting long-term brain health and memory.
Steady Support, Not a Caffeine Crash
The best part? This isn’t a stimulant. You won’t get those shaky, “I had too much espresso” jitters. Think of it less like a quick caffeine spike and more like a slow, steady stream of support for your cells.
It’s all about mitochondrial health. When your “cellular batteries” are running low, it doesn’t just feel like you’re tired. It feels like a total lack of motivation and true mental fatigue.
Why the “Pill” Version is a Game Changer
I know a lot of us in the wellness space are used to injections, but let’s be honest: sometimes we just want things to be simple.
If you’ve been looking for ways to increase energy without more shots, you are going to love this. Our version is a simple pill. No needles, no fuss, just pharmaceutical-grade support tailored to your individual needs.
Is Methylene Blue Right for You?
There is so much nuance to this conversation, especially since it’s even being studied in relation to Alzheimer’s and long-term cognitive care. Because it’s so unique (and because it turns your pee blue!), it’s hard for scientists to do “blind” studies, which is why it stays such a hot topic for research.
Professional Disclosure: I provide BS-free metabolic education as a registered nurse and health coach for women navigating PCOS, perimenopause, and stubborn weight loss. While I share evidence-based research and nurse-informed support, please remember that I am not your nurse. The content shared here is for educational purposes only. It does not constitute medical advice, diagnosis, or treatment, and it does not establish a provider-patient relationship. Nothing on this site is a substitute for care from a licensed provider who knows your full health history. All opinions and content shared on this platform are my own and do not reflect the views or endorsements of my employer or the hospital where I am employed.
Scope of Practice and FDA: Per professional coaching guidelines, I may recommend over the counter (OTC) medications or supplements to support your wellness goals. However, I do not prescribe or recommend specific prescription medications. For prescription options, including GLP-1 tools, my role is to help you understand the available science so you can have an informed discussion with your licensed healthcare provider. These statements have not been evaluated by the Food and Drug Administration. Products discussed are not intended to diagnose, treat, cure, or prevent any disease, and medical treatments require professional oversight.
Trust and Transparency: I only recommend products I trust. Most are items I use personally, while others are shared based on my professional trust in the clinical standards of partners like Ellie MD. Some links are affiliate links or part of brand partnerships, which means I may earn a commission at no extra cost to you. As an Amazon Associate I earn from qualifying purchases.
Before we even talk about glycine, we need to talk about amino acids.
Amino acids are your body’s basic building blocks. Think of them like individual beads on a necklace. One bead by itself does not look like much. But string enough of them together in the right order, and suddenly you have a necklace that actually does something.
That is how proteins work in your body. Proteins are long chains made from amino acids, and proteins are responsible for almost everything happening behind the scenes.
Hormones. Muscle repair. Healing. Immune support. Neurotransmitters that decide whether you feel calm or wired. Skin. Joints. Metabolism. All of it starts with these tiny building blocks.
Glycine as an oral amino acid supplement, often used for sleep and recovery support.
Glycine is one of those amino acids. It is small, simple in structure, and often underestimated, but it plays an important role in several systems that matter during weight loss, maintenance, and overall metabolic health.
Glycine is often used as part of GLP-1 treatment plans to support sleep, recovery, and overall metabolic health during weight loss and maintenance.
What Glycine Does in the Body (Sleep, Recovery, and Nervous System Support)
Glycine is classified as a non-essential amino acid, which means the body can produce it on its own. That does not mean the body always produces enough to meet demand, especially during periods of stress, calorie restriction, poor sleep, illness, or increased physical demands.
It plays a role in calming the nervous system. Glycine acts as an inhibitory neurotransmitter in the brain, which means it helps quiet things down rather than rev them up. That is one reason it is commonly associated with deeper, more restorative sleep.
It supports collagen production. Collagen is a major structural protein in skin, joints, connective tissue, and the gut lining. Glycine makes up a large portion of collagen’s amino acid structure, so having adequate levels matters for recovery and tissue health.
It contributes to recovery and repair. Glycine is involved in protein synthesis and cellular repair processes. These processes are especially important during weight loss, when the body is adapting to metabolic changes and repairing tissue while using stored energy.
It supports metabolic and inflammatory balance. Glycine has been studied for its role in supporting insulin sensitivity and reducing oxidative stress. These effects are supportive in nature and vary between individuals.
This is why glycine tends to feel subtle. You do not take it and feel a dramatic jolt of energy. Instead, people often notice better sleep quality, smoother recovery, and a calmer, more regulated nervous system over time.
Glycine as a Standalone Supplement
L-glycine supplement used as needed for sleep, stress, or recovery support.
The key thing to understand here is flexibility. Oral glycine is something you can adjust based on how you feel. You can take it occasionally or more consistently, depending on your needs and your provider’s guidance.
It is supportive, not forceful. It works with your system rather than pushing it.
Glycine Added to a GLP-1 or GLP-1/GIP Injection
When glycine is compounded into a GLP-1 or GLP-1/GIP injection, it is not something you take “as needed.” It becomes part of a once-weekly dosing routine, providing consistent exposure over time rather than symptom-based use.
Compounded GLP-1/GIP medication with glycine added for supportive benefits.
Instead of responding to symptoms in the moment, this approach provides your body with a steady, predictable level of glycine week after week. That consistency allows your system to use it as background support rather than a quick fix.
During active weight loss, the body is under increased physiological demand. Hormones are shifting. Metabolism is adapting. Tissues are repairing. Muscle needs support. Sleep quality often takes a hit. The nervous system can feel stressed even when weight loss is going well.
This is where glycine quietly earns its keep.
By supporting sleep quality and recovery, glycine helps your body handle the demands of weight loss more smoothly. Better sleep supports appetite regulation, stress hormones, and overall metabolic health. Recovery support matters when your body is pulling from stored energy and adapting to change.
Glycine does not directly cause weight loss. Instead, it supports the systems that help the body tolerate and sustain the process more effectively.
Glycine in Maintenance and Long-Term Regulation
Maintenance is where glycine often shines the most.
Glycine supports these goals by promoting calmer nervous system activity, supporting recovery, and contributing to overall regulation rather than stimulation.
People in maintenance often care less about pushing and more about feeling regulated. Sleeping better. Recovering more easily. Feeling calmer in their body. Glycine supports those systems without adding stimulation or stress.
For many people, maintenance is where glycine’s steady, non-disruptive support becomes most noticeable.
Weekly Glycine vs As-Needed Glycine
Weekly GLP-1 injection with glycine included for consistent background support.
This is where the two approaches can work together rather than compete.
The glycine in a weekly injection provides consistent baseline support. It is always there, quietly doing its job.
Oral glycine can be layered in as needed. Think of it as situational support for sleep disruptions, stressful weeks, or extra recovery needs.
One approach is structured and routine. The other is flexible and responsive. Together, they can support different needs at different times.
Both serve a purpose, depending on where you are in your journey and what your body is asking for.
The Takeaway
Glycine is not flashy. It does not promise overnight transformations. It does not come with dramatic sensations or instant feedback.
What it offers instead is steadiness.
Better sleep quality. Smoother recovery. Nervous system support. Structural support through collagen. Quiet metabolic assistance while your body does the heavy lifting.
Whether it is built into a weekly GLP-1 or GLP-1/GIP injection or used as an oral supplement when needed, glycine works best when you let it be what it is.
Consistent. Supportive. Calm.
Professional Disclosure: I provide BS-free metabolic education as a registered nurse and health coach for women navigating PCOS, perimenopause, and stubborn weight loss. While I share evidence-based research and nurse-informed support, please remember that I am not your nurse. The content shared here is for educational purposes only. It does not constitute medical advice, diagnosis, or treatment, and it does not establish a provider-patient relationship. Nothing on this site is a substitute for care from a licensed provider who knows your full health history. All opinions and content shared on this platform are my own and do not reflect the views or endorsements of my employer or the hospital where I am employed.
Scope of Practice and FDA: Per professional coaching guidelines, I may recommend over the counter (OTC) medications or supplements to support your wellness goals. However, I do not prescribe or recommend specific prescription medications. For prescription options, including GLP-1 tools, my role is to help you understand the available science so you can have an informed discussion with your licensed healthcare provider. These statements have not been evaluated by the Food and Drug Administration. Products discussed are not intended to diagnose, treat, cure, or prevent any disease, and medical treatments require professional oversight.
Trust and Transparency: I only recommend products I trust. Most are items I use personally, while others are shared based on my professional trust in the clinical standards of partners like Ellie MD. Some links are affiliate links or part of brand partnerships, which means I may earn a commission at no extra cost to you. As an Amazon Associate I earn from qualifying purchases.
I hear it every single day. You are exhausted, you are experiencing brain fog, and you feel like your body is fighting against you. You tell yourself you will prioritize your health “after the holidays” or “in January.”
But as a nurse, I am here to tell you that exhausted is not a personality trait. And accepting that feeling drained is “just a part of aging” is not an option.
If you have been curious about the buzz surrounding GLP-1s but are hesitant because you don’t want to just “lose weight”—or if you are in that perimenopause transition and looking for a way to feel like yourself again—it is time to look at the science of microdosing.
This isn’t about a quick fix. It is about longevity science. And right now, there is a special opportunity to start this protocol with a massive advantage (more on that at the end).
Think of microdosing as whispering to your metabolism instead of screaming at it. We aren’t trying to completely silence your appetite or force rapid changes. We are supporting the body’s natural functions to correct metabolic dysfunction.
11 Benefits of Microdosing GLP-1s (That Have Nothing to Do with the Scale)
While weight management is a fantastic side effect, the systemic benefits of this peptide therapy are what truly excite me as a healthcare provider.
1mproved Insulin Sensitivity It helps regulate blood sugar levels, making it easier to support insulin sensitivity. This is vital for reducing the risk of metabolic syndrome, which becomes much more common during perimenopause.
Hormonal Balance Support For my perimenopause and menopause ladies, this is huge. It can help manage the hormonal imbalances related to insulin and estrogen. It can also positively influence cortisol levels, reducing the toll chronic stress takes on your body.
Brain Health & Cognitive Function Brain fog is one of the biggest complaints I hear from women in midlife. GLP-1s have neuroprotective benefits that support cognitive function and mental clarity.
Cardiovascular Health It improves lipid profiles by supporting healthy cholesterol levels and reducing blood pressure by improving vascular function.
Quiet the “Food Noise” Microdosing helps suppress that constant mental chatter about food. It promotes satiety so you can make conscious, healthy eating habits without feeling deprived.
Gut Health By slowing gastric emptying, it improves digestion and nutrient absorption. A healthier gut microbiome is linked to better immunity and reduced inflammation.
Anti-inflammatory Effects Systemic inflammation is a root cause of so many chronic issues, including arthritis and skin aging. Lowering inflammation supports your whole body.
Muscle Maintenance Unlike aggressive dieting, microdosing helps preserve muscle mass. This is essential for longevity and strength as we age.
Metabolic Health Boost It enhances overall metabolic function, teaching your body to use fat as an energy source more efficiently.
Emotional Well-Being Stabilizing blood sugar levels has a direct impact on your mood. This can help reduce the anxiety and stress often associated with feeling out of control of your health.
Long-Term Prevention This is a proactive tool. It supports longevity by addressing core health issues that become prevalent in midlife, promoting overall vitality.
NAD+ is a vital coenzyme that fuels your cells. As we age, our natural levels drop, leading to fatigue and slower cellular repair. Supplementing with NAD+ provides a “cellular battery” boost.
It boosts energy by converting nutrients into ATP.
It supports DNA repair to slow the aging process.
It improves metabolism to assist with weight management.
The “Nurse’s RX” Synergy
Why do I recommend these two together? Because they solve the puzzle from two different angles. A common struggle when changing your metabolism is temporary fatigue. NAD+ directly counteracts this by boosting your cellular energy. While the Microdose regulates your hormones and insulin, the NAD+ optimizes the cellular machinery that burns the fuel. It is the ultimate “Metabolic Momentum.”
Don’t miss the biggest wellness deal of the year: Get a free month of NAD+ ($175 value) when you start your longevity microdose protocol. Valid Nov 24 – Dec 1.
You do not have to go “all in” to see changes. You just have to start. This is your chance to get a massive boost while dipping your toes into a protocol that addresses the root causes of how you feel.
Six months from now, you will be so glad you didn’t wait for January.
Professional Disclosure: I provide BS-free metabolic education as a registered nurse and health coach for women navigating PCOS, perimenopause, and stubborn weight loss. While I share evidence-based research and nurse-informed support, please remember that I am not your nurse. The content shared here is for educational purposes only. It does not constitute medical advice, diagnosis, or treatment, and it does not establish a provider-patient relationship. Nothing on this site is a substitute for care from a licensed provider who knows your full health history. All opinions and content shared on this platform are my own and do not reflect the views or endorsements of my employer or the hospital where I am employed.
Scope of Practice and FDA: Per professional coaching guidelines, I may recommend over the counter (OTC) medications or supplements to support your wellness goals. However, I do not prescribe or recommend specific prescription medications. For prescription options, including GLP-1 tools, my role is to help you understand the available science so you can have an informed discussion with your licensed healthcare provider. These statements have not been evaluated by the Food and Drug Administration. Products discussed are not intended to diagnose, treat, cure, or prevent any disease, and medical treatments require professional oversight.
Trust and Transparency: I only recommend products I trust. Most are items I use personally, while others are shared based on my professional trust in the clinical standards of partners like Ellie MD. Some links are affiliate links or part of brand partnerships, which means I may earn a commission at no extra cost to you. As an Amazon Associate I earn from qualifying purchases.
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